Insulin Impact in Glaucoma Neurodegeneration and Vascular Dysfunction
Abstract
Neurodegeneration in glaucoma remains a significant challenge, even with efforts to lower intraocular pressure (IOP). Many patients continue to experience visual field loss. This review will highlight the role that insulin signalling plays in neurodegeneration and also in vascular dysfunction. Neurodegeneration glaucoma and Alzheimer's disease (AD) share many identical characteristics, deposits of beta-amyloid, cell apoptosis, Tau hyperphosphorylation, NFT formation, and mitochondrial dysfunction with elevated OS.